منابع مشابه
Nitric Oxide is a Paracrine Mediator of Ultraviolet-induced Melanogenesis
Ultraviolet (UV) radiation is the main physiological stimulus for human skin pigmentation. Within the epidermalmelanin unit, melanocytes synthesize and transfer melanin to the surrounding keratinocytes. Keratinocytes produce paracrine factors that affect melanocyte proliferation, dendricity, and melanin synthesis. In this report, we show that normal human keratinocytes secrete nitric oxide (NO)...
متن کاملHypoxia-induced Paracrine Regulation
Vascular endothelial growth factor (VEGF)/vascular permeability factor (VPF), an endothelial cell (EC)–specific mitogen, stimulates angiogenesis in vivo, particularly in ischemic regions. VEGF/VPF expression by cells of hypoxic tissues coincides with expression of its two receptors, KDR and flt-1 , by ECs in the same tissues. We investigated whether hypoxia or hypoxia-dependent conditions opera...
متن کاملParacrine regulation of Sertoli cell proliferation
The Sertoli cell is a highly differentiated somatic cell in the seminiferous epithelium of the testis. This cell is of prime importance for both testicular development and spermatogenesis. Sertoli cells proliferate up to the start of puberty and, due to their nursing functions, the final Sertoli cell number is well correlated to the amount of germ cells produced by the adult testis. The physiol...
متن کاملEndocrine and paracrine regulation of endometrial angiogenesis.
The human endometrium is a complex tissue comprised of different cell types, including epithelial, stromal, inflammatory, perivascular, and blood vessel cells. The hormonal receptivity and distribution of these cell populations change during the menstrual cycle. Cyclical endometrial growth is dependent on its ability to regenerate a vascular capillary network, which grows in parallel with the p...
متن کامل[Regulation of melanogenesis in the dyschromia of skin].
AIM To examine the role of immune, biochemical and hormonal factors in the regulation of melanogenesis in patients with chromatopathy. PATIENTS AND METHODS We observed 226 patients with various forms dyschromia skin. Age of the patients was in the range of 16 to 55 years. The frequency of females (n = 157) prevailed over the male sex (n = 69) 2,3 times. The disease duration ranged from 3 week...
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ژورنال
عنوان ژورنال: British Journal of Dermatology
سال: 2018
ISSN: 0007-0963
DOI: 10.1111/bjd.16387